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Cell Signaling Mog (E5k6t) Xp Rabbit mAb
Cell Signaling Mog (E5k6t) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
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$152.00
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| NETA PART: | CSIG-96457T |
| MFG.PART: | 96457T |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 20 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 46, 35, 28, 23 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:100} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #85715. |
| Specificity/Sensitivity | MOG (E5K6T) Rabbit mAb recognizes endogenous levels of total MOG protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular membrane proximal amino terminus of human MOG protein. |
| Background | Myelin-oligodendrocyte glycoprotein (MOG) is a type I membrane bound glycoprotein of the immunoglobulin superfamily that is enriched in the outer lamella of the myelin sheath (1). The myelin sheath is a multi-layered membrane structure composed of oligodendrocytes that increases the conduction velocity of axonal impulses. The specific function of MOG is unknown, but MOG’s structure and expression during later stages of myelinogenesis suggests a role in myelin sheath maturation and maintenance (2). MOG may be an autoimmune target in central nervous system inflammatory diseases such as multiple sclerosis (MS) (3). Induction of MOG autoimmunity is also used as an experimental model for MS as injections of MOG peptide or recombinant protein in rodent models causes severe neurological disease that recapitulates several clinical features of MS (4). |
| SKU | CSIG-96457T |
|---|---|
| Supplier Part Number | 96457T |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |