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The product is specific for Bevacizumab. This antibody blocks Bevacizumab binding with VEGF165 (Z02689, VEGF165, Human). The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01895-40, MonoRabTM Anti-Bevacizumab Antibody (30E1), mAb, Rabbit.
Host Species
Rabbit
Immunogen
Bevacizumab
Conjugate
Biotin
Applications
Working concentrations for specific applications should be determined by the investigators. The appropriate concentration may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application
Recommended Usage
ELISA
0.01-0.05 µg/ml
Properties
Form
Lyophilized
Storage Buffer
lyophilized with PBS, pH 7.4, containing 1% BSA and 0.02% sodium azide.
Reconstitution
Reconstitute the lyophilized powder with deionized water (or equivalent) to an final concentration of 0.5 mg/mL.
Storage Instructions
The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
Purification
Protein A affinity column
Isotype
Rabbit IgG
Clonality
Monoclonal
Clone ID
46E3
Note
GenScript can customize this product per customers request including product size, buffer components, etc.
Background
Target Background
Bevacizumab (Avastin) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of patients with colon cancer, lung cancer, glioblastoma, renal-cell carcinoma, and age-related macular degeneration. As an angiogenesis inhibitor, Bevacizumab blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).
Synonyms
Rabbit Monoclonal to Avastin
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
