Miltenyi Biotec Ly-6g Antibody, Anti-Mouse, Fitc, Realease®

Miltenyi Biotec Clone REAL176 is an antibody fragment derived from the full Ly-6G antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. | Clone REAL176 recognizes the mouse Ly-6G (Lymphocyte antigen 6G) antigen, a 21-25-kDa glycosylphosphatidylinositol (GPI) linked protein which is highly expressed on neutrophilic granulocytes. Expression greatly increases during granulocyte maturation. To a lower extent, Ly-6G is also expressed during the development of monocytes. In mouse bone marrow samples, Ly-6G is primarily detected on granulocytes, but not on lymphocytes or erythrocytes. Ligation of Ly-6G in animals with an underlying background inflammation (induced by TNF-α) leads to profound cardiovascular and respiratory responses, including severe breathing difficulties, leukocyte and platelet aggregation, and coagulation, leading to microvessel obstruction and subsequent death. | The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes. - MLTY (Additional S&H or Hazmat Fees May Apply)