Miltenyi Biotec Ror1 Antibody, Anti-Human, Vio® Bright V423, Reafinity™

Miltenyi Biotec Clone REA1051 recognizes the human ROR1 antigen, also known as receptor tyrosine kinase-like orphan receptor 1. ROR1 has characteristics of an oncofetal gene and was recently identified to be overexpressed at the gene and protein levels in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). ROR1 expression has also been detected in ovarian cancer, renal cancer, melanoma, and lung adenocarcinoma, suggesting a general role of ROR1 in cancer genesis and/or maintenance. Moreover, ROR1 expression has been found in undifferentiated embryonic stem cells, in adipose tissue, at early stages of B cell development, but not in major adult tissues. Therefore, ROR1 is a potential therapeutic target and a biomarker to identify and enumerate malignant cells in CLL and MCL blood samples via flow cytometry. | Additional information: Clone REA1051 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)