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Miltenyi Biotec Cd354 (Trem-1) Antibody, Anti-Mouse, Apc-Vio® 770, Reafinity™
Miltenyi Biotec Identification And Enumeration Of Cd354 (Trem-1)+ Cells By Flow Cytometry - MLTY (Additional S&H or Hazmat Fees May Apply)
List Price
$159.50
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$159.50
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NETA PART: | MLTY-130-130-026 |
MFG.PART: | 130-130-026 |
UNSPSC: | 12352203 |
Manufacturer: | Miltenyi Biotec |
Miltenyi Biotec Clone REA191 recognizes murine CD354 (TREM-1), a 30 KDa member of TREM (triggering receptors expressed on myeloid cells) family of cell surface receptors. TREM receptors are immunoglobulin superfamily members and contain a single variable-type immunoglobulin domain. Murine TREM cluster is located on chromosome 17C. Expression of TREM-1 is found on cell surface of myeloid cells such as neutrophils, monocytes, dendritic cells and macrophages. TREM-1 signals via ITAM-containing adaptor DAP12 and serves as an amplifier of cell activation in response to triggers such as LPS . TREM-1 activated cellular signalling molecules and pathways lead to generation of pro-inflammatory response such as expression and secretion of chemokines and cytokines including MCP-1, MIP-1α, IL-6,-8 TNF. TREM-1 acts in a concerted manner with other signalling receptors as TLRs and Nod-like receptors, leading to an amplification of initial response. Expression of TREM-1 itself is upregulated in response to presence of LPS, microbial products and cytokines released during activation response. A soluble form of TREM-1 (sTREM-1) is also detected in serum of mouse infection, sepsis and granulomatous disease models. | Additional Information: Clone REA191 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)
SKU | MLTY-130-130-026 |
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Supplier Part Number | 130-130-026 |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Miltenyi Biotec |
MSDS URL | https://www.miltenyibiotec.com/ds/130-130-026 |
ProductLine | MLTY |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |