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Tonbo Pe Anti-Mouse Cd279 (Pd-1) (J43.1)
NETA PART: | TB-50-9985-U025 |
MFG.PART: | 50-9985-U025 |
UNSPSC: | 12352203 |
Manufacturer: | Tonbo |
The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with B7 ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.
The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo. Please choose the appropriate format for each application.
- TB (Additional S&H or Hazmat Fees May Apply)SKU | TB-50-9985-U025 |
---|---|
Supplier Part Number | 50-9985-U025 |
UM | UNIT |
UNSPSC | 12352203 |
Manufacturer | Tonbo |
Temperature | -20 |
Refrigerated-Frozen | Y |
CountryOfOrigin | United States |
ProductLine | TB |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |