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Cell Signaling Cd11b/Itgam (M1/70) Rat mAb (Pe Conjugate)
Cell Signaling Cd11b/Itgam (M1/70) Rat mAb (Pe Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$103.00
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$103.00
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NETA PART: | CSIG-24965S |
MFG.PART: | 24965S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µg |
Reactivity | H M |
Sensitivity | Endogenous |
Source/Isotype | Rat IgG2b kappa |
Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:160, Flow Cytometry (Live): 1:160} |
Storage | Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze. |
Specificity/Sensitivity | CD11b/ITGAM (M1/70) Rat mAb (PE Conjugate) recognizes endogenous levels of total CD11b protein. This antibody detects an epitope within the extracellular domain. |
Species Reactivity | Human, Mouse |
Source/Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. |
Background | Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the bloodstream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematosus (SLE) (4).The M1/70 antibody is widely used as a marker for CD11b expression on neutrophils, macrophages, NK cells, and dendritic cells (DC) (5,6). |
SKU | CSIG-24965S |
---|---|
Supplier Part Number | 24965S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
CountryOfOrigin | US |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |