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Cell Signaling Cd8alpha (Rpa-T8) Mouse mAb (Violetfluor 450 Conjugate)
Cell Signaling Cd8alpha (Rpa-T8) Mouse mAb (Violetfluor 450 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$278.00
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$278.00
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NETA PART: | CSIG-25109S |
MFG.PART: | 25109S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 500 µl (100 tests) |
Reactivity | H |
Sensitivity | Endogenous |
Source/Isotype | Mouse IgG1 |
Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:20, Flow Cytometry (Live): 1:20} |
Storage | Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze. |
Specificity/Sensitivity | CD8α (RPA-T8) Mouse mAb (violetFluor™ 450 Conjugate) recognizes endogenous levels of total CD8α protein. This antibody detects an epitope within the extracellular domain. |
Species Reactivity | Human |
Source/Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. |
Background | Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).The RPA-T8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells and thymocytes (2,3), as well as on certain cell types that do not express the TCR, including some NK cells (4). |
SKU | CSIG-25109S |
---|---|
Supplier Part Number | 25109S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | +4C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |