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Cell Signaling Pcna (Pc10) Mouse mAb
Cell Signaling Pcna (Pc10) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$138.00
Your Price
$138.00
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NETA PART: | CSIG-2586T |
MFG.PART: | 2586T |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H M R Mk B Pg |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 36 |
Source/Isotype | Mouse IgG2a |
Application/Dilution | {Western Blotting: 1:2000, Immunoprecipitation: 1:100, Immunohistochemistry (Paraffin): 1:8000 - 1:32000, Immunofluorescence (Immunocytochemistry): 1:1600 - 1:3200, Flow Cytometry (Fixed/Permeabilized): 1:400} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | PCNA (PC10) Mouse mAb detects endogenous levels of PCNA protein. |
Species Reactivity | Human, Mouse, Rat, Monkey, Bovine, Pig |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a recombinant Protein A-PCNA fusion protein obtained from pC2T. |
Background | Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (1). Crystal structure data suggests that a PCNA homotrimer ring can encircle and slide along the DNA double helix (2). Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA (reviewed in 3). PCNA protein expression is a well-accepted marker of proliferation. |
SKU | CSIG-2586T |
---|---|
Supplier Part Number | 2586T |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |