We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cell Signaling Fibrillarin (C13c3) Rabbit mAb
Cell Signaling Fibrillarin (C13c3) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$138.00
Your Price
$138.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CSIG-2639T |
MFG.PART: | 2639T |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 20 µl |
Reactivity | H M R Mk |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 37 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Frozen): 1:50, Immunofluorescence (Immunocytochemistry): 1:400} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Fibrillarin (C13C3) Rabbit mAb detects endogenous levels of total fibrillarin protein. |
Species Reactivity | Human, Mouse, Rat, Monkey |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide surrounding Thr298 of human fibrillarin. |
Background | Fibrillarin is a 2-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place (1,2). Fibrillarin associates with several other structural proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. This complex catalyzes site-specific 2-O-ribose methylation of targeted nucleotides within the rRNA sequence (3,4). The sequence, structure, and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development (5). |
SKU | CSIG-2639T |
---|---|
Supplier Part Number | 2639T |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |
Hazardous | N |