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Cell Signaling Il2-Ralpha/Cd25 (Pc61.5) Rat mAb (Fitc Conjugate)
Cell Signaling Il2-Ralpha/Cd25 (Pc61.5) Rat mAb (Fitc Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$114.00
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$114.00
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NETA PART: | CSIG-63448S |
MFG.PART: | 63448S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µg |
Reactivity | M |
Sensitivity | Endogenous |
Source/Isotype | Rat IgG1 lambda |
Application/Dilution | {Flow Cytometry (Live): 1:400} |
Storage | Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze. |
Specificity/Sensitivity | IL2-Rα/CD25 (PC61.5) Rat mAb (FITC Conjugate) recognizes endogenous levels of total IL2-Rα/CD25 protein. This antibody detects an epitope within the extracellular domain. |
Species Reactivity | Mouse |
Source/Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. |
Background | Interleukin-2 (IL-2) is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of regulatory T cells (Tregs) (3,4). Conversely, IL-2 is involved in the activation-induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (5). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ, and the common gamma chain, γc (1,2). IL-2Rα binds exclusively to IL-2 with low affinity and increases the binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ (1,2). γc is used by other cytokines, including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5, and the PI3K/Akt pathways (1,2). |
SKU | CSIG-63448S |
---|---|
Supplier Part Number | 63448S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | +4C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |