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Cell Signaling Cd11b/Itgam (M1/70) Rat mAb (Violetfluor 450 Conjugate)
Cell Signaling Cd11b/Itgam (M1/70) Rat mAb (Violetfluor 450 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$222.00
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$222.00
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| NETA PART: | CSIG-70078S |
| MFG.PART: | 70078S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µg |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Source/Isotype | Rat IgG2b kappa |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:160, Flow Cytometry (Live): 1:160} |
| Storage | Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze. |
| Specificity/Sensitivity | CD11b/ITGAM (M1/70) Rat mAb (violetFluor™ 450 Conjugate) recognizes endogenous levels of total CD11b protein. This antibody detects an epitope within the extracellular domain. |
| Species Reactivity | Human, Mouse |
| Source/Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. |
| Background | Cluster of differentiation molecule 11b (CD11b)/Integrin alpha M (ITGAM) is a transmembrane protein forming heterodimers that are composed of α and β subunits (1). CD11b is expressed by, and commonly used as a marker for, myeloid lineage cells, including neutrophils, monocytes, macrophages, and microglia (2). CD11b is phosphorylated at Ser1126 (cytoplasmic tail) in neutrophils. Research has shown that this phosphorylation event plays a role for leukocytes traveling from the bloodstream to tissues (3). Furthermore, genome-wide association studies have linked CD11b to autoimmune diseases, such as systemic lupus erythematosus (SLE) (4).The M1/70 antibody is widely used as a marker for CD11b expression on neutrophils, macrophages, NK cells, and dendritic cells (DC) (5,6). |
| SKU | CSIG-70078S |
|---|---|
| Supplier Part Number | 70078S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |