We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cell Signaling Cd20 (2h7) Mouse mAb (Violetfluor 450 Conjugate)
Cell Signaling Cd20 (2h7) Mouse mAb (Violetfluor 450 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$296.00
Your Price
$296.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CSIG-88560S |
| MFG.PART: | 88560S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 500 µl (100 tests) |
| Reactivity | H |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG2b kappa |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:20, Flow Cytometry (Live): 1:20} |
| Storage | Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze. |
| Specificity/Sensitivity | CD20 (2H7) Mouse mAb (violetFluor™ 450 Conjugate) recognizes endogenous levels of total CD20 protein. This antibody detects an epitope within the extracellular domain. |
| Species Reactivity | Human |
| Source/Purification | This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. |
| Background | B-lymphocyte antigen CD20 (also known as MS4A1; Membrane-spanning 4-domains subfamily A member 1) is a cell surface phosphoprotein involved in the regulation of B cell activation and proliferation (1,2). It is commonly used as a marker to identify B cells and is expressed throughout B cell development, up until their differentiation into plasma cells. CD20 has no known ligand, and its expression and function are largely conserved between human and mouse (1-3). Evidence suggests that CD20 is necessary for store operated calcium (SOC) entry, which leads to elevated cytoplasmic calcium levels required for B cell activation (4,5). Anti-CD20 antibody immunotherapy depletes B cells by activation of the innate monocytic network and is a common treatment for B cell lymphomas, leukemias, and autoimmune diseases (6).The 2H7 antibody is widely used to identify both normal and malignant B cells (7). |
| SKU | CSIG-88560S |
|---|---|
| Supplier Part Number | 88560S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | +4C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |