We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cell Signaling Ucp2 (D1o5v) Rabbit mAb
Cell Signaling Ucp2 (D1o5v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
Your Price
$327.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CSIG-89326S |
| MFG.PART: | 89326S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 32 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | UCP2 (D1O5V) Rabbit mAb recognizes endogenous levels of total UCP2 protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly153 of human UCP2 protein. |
| Background | Uncoupling protein 2 (UCP2) is a mitochondrial inner membrane transport protein that is expressed in a wide range of tissues (1). UCP2 inhibits mitochondrial glucose oxidation and promotes glycolysis in human pluripotent stem cells (hPSCs) (2). During early differentiation of hPSCs, the expression of UCP2 is repressed, which results in reduced glycolysis (2). This demonstrates a role for UCP2 in the metabolic reprogramming during differentiation of hPSCs (2). Overexpression of UCP2 in cancer cells stimulates oxidative phosphorylation in mitochondria and inhibits cell proliferation (3). |
| SKU | CSIG-89326S |
|---|---|
| Supplier Part Number | 89326S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |