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Tonbo Percp Anti-Mouse Cd4 (Rm4-5)
NETA PART: | TB-67-0042-U100 |
MFG.PART: | 67-0042-U100 |
UNSPSC: | 12352203 |
Manufacturer: | Tonbo |
The RM4-5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta2-domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The RM4-5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the RM4-5 antibody and an alternative antibody, Anti-Mouse CD4 clone GK1.5, will compete for binding, i.e. RM4-5 antibody is able to block GK1.5 antibody binding to cells. In contrast, RM4-5 antibody does not block the binding of Anti-Mouse CD4 clone RM4-4 to cells.
- TB (Additional S&H or Hazmat Fees May Apply)SKU | TB-67-0042-U100 |
---|---|
Supplier Part Number | 67-0042-U100 |
UM | UNIT |
UNSPSC | 12352203 |
Manufacturer | Tonbo |
Temperature | -20 |
Refrigerated-Frozen | Y |
CountryOfOrigin | United States |
ProductLine | TB |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |