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Genscript IL-10, Rat (CHO-expressed)
Genscript IL-10, Rat (CHO-expressed) - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$2,230.00
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$2,230.00
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NETA PART: | GSCRPT-Z03171-1 |
MFG.PART: | Z03171-1 |
UNSPSC: | 41106514 |
Manufacturer: | GenScript USA Inc |
Product Introduction
Species | Rat | |
Protein Construction |
| |
Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC | |
Endotoxin Level | < 0.2 EU/μg of protein by gel clotting method | |
Biological Activity | ED50 < 8.0 μg /ml, measured in a bioassay using C6 cells. | |
Expression System | CHO | |
Apparent Molecular Weight | 8~22 kDa, on SDS-PAGE under reducing conditions. | |
Formulation | Lyophilized after extensive dialysis against PBS. | |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
Target Background | Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with the Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays the ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported. |
Synonyms | B-TCGF; CSIF; TGIF |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
SKU | GSCRPT-Z03171-1 |
---|---|
Supplier Part Number | Z03171-1 |
UM | EA |
UNSPSC | 41106514 |
Manufacturer | GenScript USA Inc |
ProductLine | GSCRPT |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 7 Business Days |