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Genscript IFN-γ, Rat
Genscript IFN-γ, Rat - GSCRPT (Additional S&H or Hazmat Fees May Apply)
List Price
$925.00
Your Price
$925.00
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| NETA PART: | GSCRPT-Z03584-1 |
| MFG.PART: | Z03584-1 |
| UNSPSC: | 41106514 |
| Manufacturer: | GenScript USA Inc |
Product Introduction
| Species | Rat | |
| Protein Construction |
| |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC | |
| Endotoxin Level | < 0.1 EU/µg of protein by LAL method | |
| Biological Activity | The ED50 as determined by an anti-viral assay using murine L929 cells infected with encephalomyocarditis (EMC) virus is less than 0.1 ng/ml, corresponding to a specific activity of 1.0 × 107 IU/mg. | |
| Expression System | E. coli | |
| Theoretical Molecular Weight | 15.5 kDa | |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 1 × PBS, pH 7.4, 1 mM DTT, 5 % Trehalose and 0.05 % Tween-80. | |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in 10 mM HAc to a concentration of 0.1-1.0 mg/ml. | |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -20°C or -70°C. Upon reconstitution, the product should be stable for up to 1 week at 2-8°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Interferon-gamma (IFN-γ), also known as Type II interferon or immune interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. It shares high sequence indentity with mouse IFN-γ (86 %). IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally, IFN-γ augments TH1 cell expansion and may be required for TH1 cell differentiation. |
| Synonyms | Type II interferon; T cell interferon; MAF |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03584-1 |
|---|---|
| Supplier Part Number | Z03584-1 |
| UM | EA |
| UNSPSC | 41106514 |
| Manufacturer | GenScript USA Inc |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 7 Business Days |