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Cell Signaling Vps29 (D2h7g) Rabbit mAb
Cell Signaling Vps29 (D2h7g) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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NETA PART: | CSIG-73540S |
MFG.PART: | 73540S |
UNSPSC: | 41116012 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M R |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 21 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | VPS29 (D2H7G) Rabbit mAb recognizes endogenous levels of total VPS29 protein. |
Species Reactivity | Human, Mouse, Rat |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala121 of human VPS29 protein. |
Background | Retromer is a heteropentameric protein complex that consists of two protein compounds, a sortin-nexin dimer and a trimeric VPS26-VPS29-VPS35 protein subcomplex. The retromer complex associates with endosomes at their cytosolic side to mediate retrograde transport of transmembrane proteins from endosomes to the trans-Golgi network (1-3). Vacuolar protein sorting-associated protein 29 (VPS29) is considered a cryptic metallophosphoesterase, as it contains a conserved metallophosphoesterase-fold that includes a phenylalanine in place of an essential histidine residue within the active site (4). While VPS29 is capable of binding metal ions, it does so with low affinity and exhibits no enzymatic activity. Instead, VPS29 serves as a scaffold protein that interacts with the carboxy-terminal region of VPS35 and is essential for association of the retromer with other endosomal transport proteins (5). |
SKU | CSIG-73540S |
---|---|
Supplier Part Number | 73540S |
UM | UNIT |
UNSPSC | 41116012 |
Manufacturer | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |