Beckman Cd8-Rd1, Sfci21thy2d3, 100 Tests, Ce, Ivd

Beckman the cd8 antigen is a disulfide-linked dimer, which exists either as a cd8α homodimer or as a cd8α/β heterodimer. cd8α is required for surface expression of cd8β. the molecular weight of each monomer of α or β is approximately 32-34 kda. cd8 binds to a non-polymorphic domain (α3 domain) of mhc class i molecules. cd8 is expressed on a subset of human peripheral blood t lymphocytes. a subset of nk cells possess the cd8 antigen but show low to medium density of expression. cd8α homodimer is expressed by nk cells and γ/δ+ t cells. cd8 is also present on most thymocytes where it is frequently co-expressed with cd4, and on a subpopulation of bone marrow cells. the cd8 molecule acts with the t cell receptor (tcr) as a coreceptor for mhc class i restricted antigen recognition. cd8 is widely used as a marker of cytotoxic t lymphocytes. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)