Beckman Cd41-Pc5, P2, 100 Tests, Ruo

Beckman the cd41 antigen (platelet gpiib; iib integrin) is a transmembrane glycoprotein composed of two chains gpiibα (120 kda) and gpiibβ (23 kda) linked by one disulfide bond. cd41 is always non-covalently associated with cd61 (platelet gpiiia, β3 integrin), to form the gpiib-iiia (cd41/cd61) complex. cd41 is expressed by platelets, megakaryocytes and a small subset of cd34+ cells, suggesting that cd41/cd61 is one of the earliest markers of the megakaryocytic lineage. the resting form of the cd41/cd61 complex binds to immobilized fibrinogen and upon platelet activation, the complex becomes a receptor for soluble fibrinogen, fibronectin, vwf, vitronectin and thrombospondin. it is involved in platelet aggregation. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)