Beckman Cyclin A2-Fitc, 11b2g3, 2 Ml, Asr

Beckman in humans, there are two a-type cyclins – an embryonic-specific cyclin a1 and a somatic cyclin a2. cyclin a1 is only expressed in meiosis and very early embryos, whereas cyclin a2 is present in proliferating somatic cells. cyclin a2 is a 48 kda protein composed of 432 amino-acids. cyclins control the activation of cyclin dependent kinases (cdks) by associating with them to form a cyclin-cdk complex able to phosphorylate selected proteins and to induce downstream processes. the cyclin a2-cdk2 complex initiates dna replication and is required for s phase progression. for passage through g2 to m phase, cyclin a2 complexes to the cdk1 (also called cdc2). cyclin a2 is degraded via the ubiquitin-dependant proteolysis pathway in the early phases of mitosis. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)