Beckman Cd278-Pe, Isa-3, 100 Tests, Ruo

Beckman the cd278 antigen, also known as icos molecule (inducible t-cell costimulator, inducible costimulator), is a disulfide-linked homodimeric t-cell surface glycoprotein of 55-60 kda, which belongs to the cd28 and ctla-4 cell-surface receptor family. the cd278 molecule plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. while cd278 antigen is not constitutively expressed on naã¯ve peripheral blood t cells, it is highly expressed on unstimulated thymocytes of germinal centers, showing a role in t cell differentiation. upon activation by antigen presenting cells, t cells (cd4 positive cells and cd8 positive cells) express inducible co-stimulatory receptors, including cd28, ctla4 and icos. the resulting interaction of cd278 (icos) with its ligand icos-l (b7-like molecule present on b cells) participates to interleukin production, especially il-10 and il4. the central role of cd278 in the generation and maintenance of humoral immunity has also been shown to be important. upon the co-stimulation of t cells through icos and cd28, icos binds its ligand icos-l leading to igg and igm secretion as well as ige production. it is not expressed on resting peripheral t cells, b cells, nk cells, monocytes/macrophages, platelets and granulocytes. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)