Beckman Cd38-Pc5.5, Ls198-4-3, 0.5 Ml, Asr

Beckman the cd38 antigen is a 45 kda single chain type ii integral membrane glycoprotein, with the nh2-terminus inside the cytoplasm. cd38 is an enzyme with several activities such as nad glycohydrolase, adp ribosylcyclase and cyclic adp ribose hydrolase. cd38 is expressed on activated t and b lymphocytes, nk cells, monocytes, plasma cells and medullary thymocytes. cd38 expression appears to depend on the differentiation and activation of the cell. in the b cell lineage, cd38 is expressed in early stages of b-cell ontogeny, lost during maturation and re-expressed upon terminal differentiation to plasma cells. similarly, cd38 is expressed on thymocytes and at a high level on activated t cells. most mature resting lymphocytes of both b and t lineages do not express the cd38 antigen. cd38 is widely used as a marker to study t and b lymphocyte activation. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)