Beckman Hla-Abc-Unlb, B9.12.1, 0.2 Mg, Ruo

Beckman hla-a, -b, and -c are major histocompatibility complex (mhc)-class i antigens. like other class i molecules (i.e. hla-e, -f, -g), hla-a, -b, and -c are heterodimers consisting of a 40 – 45 kda transmembrane glycoproteic α-chain, noncovalently combined to the invariant β2-microglobulin. all class i molecules have conserved, monomorphic domains, but are also characterized by their extensive degree of allelic polymorphism. mhc molecules play a central role in the immune response. they are involved in the maturation of t cell repertoire, in the activation of t lymphocytes by presentation of xenogenic peptides or in the allogenic response. hla-a, -b and -c are "classical" mhc class i molecules and are expressed on the surface of most nucleated human cell types. - BKMPFZ (Additional S&H Or Hazmat Fees May Apply)