Revvity Htrf Human Androgen Receptor Detection Kit, 500

Revvity The Htrf Human Androgen Receptor Detection Assay Monitors Wild-Type Androgen Receptor (Ar-Wt) And The Androgen Receptor Splice Variant 7 (Ar-V7), And Is Used To Detect The Expression Of Endogenous Or Overexpressed Androgen Receptors In Various Cells. Androgen Receptor Is A Type Of Nuclear Receptor That Is Activated By Androgen Hormones, Like Testosterone (T) And Dihydrotestosterone (Dht). Androgens Bind To The Ligand Binding Domain Of The Androgen Receptor, Resulting In Receptor Homodimerization And Translocation To The Nucleus. This Activates Downstream Gene Expression And Activation Of Signaling Pathways, Like The Pi3k/Akt Pathway. The Gene Expression Induced By Androgen Receptor Results In Cell Division, Proliferation, Differentiation, Apoptosis, And Angiogenesis. A Dysregulation Of The Androgen Receptor Pathway Could Lead To Oncogenic Phenotypes, And Androgen Receptor Activation Or Surexpression Has Been Widely Linked To Prostate Cancer As Well As Other Types Of Cancer, Like Breast Cancer And Glioblastoma. Moreover, Androgen Receptor Variants Are Expressed In Various Human Cancer Cell Lines. The Androgen Receptor Variant 7 (Ar-V7), A Splice Variant Of The Androgen Receptor Mrna Resulting In The Truncation Of The Ligand-Binding Domain, Is Constitutively Active And Widely Expressed In Human Cancer Cell Lines. Androgen Receptor Has Therefore Become An Important Drug Target For The Pharmaceutical Industry. The Development Of Protac Compounds To Target Androgen Receptor Degradation Is A Part Of The Therapeutic Strategy To Target Androgen Receptor Positive Cancers. - PEGSK (Additional S&H Or Hazmat Fees May Apply)