Revvity Total Syk Cellular Kit, 10000 Tests

Revvity The Total Syk Cellular Assay Monitors Total Syk, And Can Be Used As A Normalization Assay With Our Phospho-Syk (Tyr525/526) Kit. This Kit Is Compatible With The Buffers From The Phospho-Syk Kit, So The Same Lysate Can Be Used For Analyses Of Both The Phosphorylated And The Total Protein Populations.  Syk (Spleen Tyrosine Kinase) Is A Cytoplasmic Tyrosine/Serine Kinase Which Plays A Crucial Role In Signal Transduction, Especially In Immune Cells Such As B Cells, Macrophages, Microglia (Brain-Resident Macrophages), Neutrophils And Mast Cells. Upon Cell Stimulation, Syk Interacts With The Cytoplasmic Domains Of Activated Immune Receptors And Binds To The Specific Phosphorylated Receptor Motifs (Called "P-Itams"), Leading To Its Activation By Auto-Phosphorylation Of Its Catalytic Domain At Tyr525/526.  Syk Phosphorylation Is A Readout Of Key Inflammatory Pathways Such As Bcr, Fcr And Trem2 Signaling Pathways That Are Altered In Various Pathologies Such As Auto-Immune Diseases, Neurodegeneration, Cancers And Allergic Disorders.   S - PEGSK (Additional S&H Or Hazmat Fees May Apply)