Revvity Phospho-Syk (Tyr525/526)

Revvity This Htrf Cell-Based Assay Conveniently And Accurately Detects Phosphorylated Syk At Tyr525/526. Syk (Spleen Tyrosine Kinase) Is A Cytoplasmic Tyrosine/Serine KinaseWhich Plays A Crucial Role In Signal Transduction, Especially In Immune Cells Such As B Cells, Macrophages, Microglia (Brain-ResidentMacrophages), Neutrophils And Mast Cells. Upon Cell Stimulation, SykInteracts With The Cytoplasmic Domains Of Activated Immune Receptors And Binds To The Specific Phosphorylated Receptor Motifs (Called "P-Itams"), Leading To ItsActivation ByAuto-Phosphorylation Of Its Catalytic Domain At Tyr525/526. Syk Phosphorylation Is A Readout Of Key Inflammatory Pathways Such As Bcr, Fcr And Trem2 Signaling Pathways That Are Altered In Various Pathologies Such As Auto-Immune Diseases,Neurodegeneration, Cancers And Allergic Disorders. S - PEGSK (Additional S&H Or Hazmat Fees May Apply)